ADENINE IN RED CELL PRESERVATION*
نویسندگان
چکیده
منابع مشابه
Adenine in Red Cell Preservation
Purine nucleosides have been reported to extend the preservation of red cells stored in acid citrate dextrose (ACD) (1-6). This effect was originally attributed to the production of phosphorylated ribose as an energy substrate within the erythrocyte (7-9) through the action of nucleoside phosphorylase (10). This enzyme was shown to act on inosine, guanosine (11, 12), and on adenosine after its ...
متن کاملRed cell preservation: further studies with adenine.
I N A PREVIOUS COMMUNICATION’ we have shown that supplementing the acid citrate dextrose ( ACD ) preservative with small amounts of adenine (0.75 :: 0.25 ‘! per ml. ACD-blood) at the beginning of the storage period preserves satisfactory viability ( post-transfusion survival greater than 70 per cent ) of stored human erythrocytes for at least 5 weeks. Larger amounts of adenine were less effecti...
متن کاملThe Mechanism of Action of Adenine in Red Cell Preservation * YOSHIKI SUGITA t AND ERNEST
Nakao and his associates have demonstrated that when blood, which had previously been stored at 40 C for 8 to 10 weeks in acid-citratedextrose (ACD), was subsequently incubated at 370 C with both adenine and inosine, regeneration of ATP and restoration of post-transfusion viability took place (1-3). ATP regeneration did not occur when the incubation medium contained either adenine or inosine al...
متن کاملEffect of inosine on red cell preservation.
to be the same. However, since some samples of blood stored in ACDI in the present study did give satisfactory survival results at 35 and 42 days, it has been suggested that red cells of different individuals may vary in their ability to withstand prolonged storage. It should be noted that the purine nucleosides are metabolized to uric acid. While in healthy volunteers the transfusion of450 ml ...
متن کاملRed blood cell metabolism, preservation, and oxygen delivery
A human red cell, mature and released from the bone marrow, lacks a nucleus and mitochondria. It has a life span of 120 days, after which it is removed from the circulation in the natural course of aging. It picks up oxygen in a third of a second transit of the alveolar capillary and delivers oxygen through capillaries with a smaller diameter than its own. It can neither use oxygen for the extr...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1962
ISSN: 0021-9738
DOI: 10.1172/jci104489